Enhancing treatment of osteoarthritis knee pain by boosting expectancy: A functional neuroimaging study


Autor: JianKong et al


Journal: NeuroImage: Clinical Volume 18, 2018, Pages 325-334, englisch


Objectives
Expectation can significantly modulate pain and treatment effects. This study aims to investigate if boosting patients' expectancy can enhance the treatment of knee osteoarthritis (KOA), and its underlying brain mechanism.

Methods
Seventy-four KOA patients were recruited and randomized to three groups: boosted acupuncture (with a manipulation to enhance expectation), standard acupuncture, or treatment as usual (TAU). Each patient underwent six treatments before being debriefed, and four additional treatments after being debriefed. The fMRI scans were applied during the first and sixth treatment sessions.

Results
We found significantly decreased knee pain in the boosted acupuncture group compared to the standard acupuncture or TAU groups after both six and ten treatments. Resting state functional connectivity (rsFC) analyses using the nucleus accumbens (NAc) as the seed showed rsFC increases between the NAc and the medial prefrontal cortex (MPFC)/rostral anterior cingulate cortex (rACC) and dorsolateral prefrontal cortex in the boosted group as compared to the standard acupuncture group after multiple treatments. Expectancy scores after the first treatment were significantly associated with increased NAc-rACC/MPFC rsFC and decreased knee pain following treatment.

Conclusions
Our study provides a novel method and mechanism for boosting the treatment of pain in patients with KOA. Our findings may shed light on enhancing outcomes of pharmacological and integrative medicines in clinical settings.


Andere Benutzer haben sich neben diesem auch noch folgende Artikel angesehen:

Current Status and Major Challenges to the Safety and Efficacy Presented by Chinese Herbal Medicine
Xian Zhou et al; 2019

The Contribution of Complementary and Alternative Medicine to Reduce Antibiotic Use
Baars E et al; 2019

What do we understand from clinical and mechanistic studies on acupuncture treatment for hypertension?
Ling Cheng et al; 2019




 
 

Vorheriger Artikel

Übersicht

Nächster Artikel
 

Link zum Journal