OBJECTIVE: To evaluated the effectiveness and safety of Chinese herbal medicines (CHMs) for coro- nary heart disease (CHD) complicated with anxiety.
METHODS: Randomized controlled clinical trials (RCTs) with parallel-groups were included after searching through electric-databases from incep- tion to May, 2017. Meta-analysis was undertaken with RevMan 5.3 software.
RESULTS: Twenty-three RCTs enrolling 1654 pa- tients were included in this systematic review. The combination therapy (CHMs combined with anxio- lytic) appeared to be superior to anxiolytic in terms of reducing the score of Zung Self-rating Anxiety scale (SAS) (mean Difference (MD), - 12.25; 95% confidence interval (CI), - 14.01 to - 10.48, elimi- nating method; MD, -3.92; 95% CI, -5.48 to -2.35, tranquilizing method), improving the total effect
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rate (relative risk (RR), 1.26; 95% CI, 1.08 to 1.46, eliminating method) and reducing the TCM symp- toms scores (MD, -2.24; 95% CI, -4.25 to -0.23, tranquilizing method) with a lower incidence of ad- verse events (RR, 0.46; 95% CI, 0.25 to 0.85, tonify- ing method). CHMs demonstrated benefits in low- ering the score of Hamilton Anxiety Rating scale (MD, - 6.77; 95% CI, - 8.16 to - 5.37, tonifying method),lowering the score of SAS (MD, - 10.1; 95% CI, -13.73 to -6.30, tonifying method) and reducing the TCM symptoms scores (MD, - 2.18; 95% CI, -3.12 to -1.24, tranquilizing method).
CONCLUSION: We got a low evidence that CHMs, which had less side effects, showed potentially ben- efits to patients with CHD complicated with anxi- ety. While the results should be interpreted with caution. Trails with higher quality are required to verify the effectiveness and safety of CHMs for CHD complicated with anxiety.
Efficacy and Safety of Jiawei Suanzaoren Decoction Combined with Lorazepam for Chronic Insomnia
Ming-Fen Song et al.; 2020