Efficacy of Acupuncture and Moxibustion as a Subsequent Treatment after Second-Line Chemotherapy in Advanced Gastric Cancer


Autor: Yong-jie Zhang et al


Journal: Evidence-Based Complementary and Alternative Medicine Volume 2020, Article ID 8274021, englisch


Objective.
To explore whether acupuncture and moxibustion can prevent disease progression of advanced gastric cancer patients completing second-line chemotherapy and, if so, the related mechanism.
Method.
Progression-free survival (PFS) and overall survival (OS) were main outcome measures. The real-time quantitative PCR was used to detect the expression of genes including T-bet, IFN-γ, GATA3, and IL-4 in peripheral blood mononuclear cells (PBMCs). IL-4, IL-6, Ca199, CRP, and IFN-γ in plasma levels were checked.
Results.
170 patients were randomly assigned in a 3 : 2 ratio to receive either acupuncture and moxibustion or sham acupuncture until progression. 135 patients were included in the primary analysis. Both PFS and OS in treatment group were proven to be better than control group. Acupuncture and moxibustion promoted typical Th1 cells drifting, as confirmed by increased T-bet/IFN-γ and decreased GATA3/IL-4 in mRNA levels from PBMCs, as well as upregulating IFN-γ and downregulating IL-4 in plasma levels. IL-6, Ca199, and CRP in plasma levels were also reduced by acupuncture and moxibustion.
Conclusions.
Acupuncture and moxibustion can prolong PFS and OS of advanced gastric cancer patients completing second-line chemotherapy by reversing Th1/Th2 shift and attenuating inflammatory responses.


Andere Benutzer haben sich neben diesem auch noch folgende Artikel angesehen:

Optimal acupoint and session of acupuncture for patients with chronic prostatitis/chronic pelvic pain syndrome
Wei Zhang et al; 2021

Acupuncture for post-operative cognitive dysfunction
Yidan Tang et al; 2020

Mobility network models of COVID-19 explain inequities and inform reopening
Serina Chang et al; 2020




 
 

Vorheriger Artikel

Übersicht

Nächster Artikel
 

Link zum Journal