As the novel coronavirus disease 2019 (COVID-19) and its variants continue to rage into the second year of a global pandemic, many success stories of applying Chinese herbal medicine (CHM) to treat COVID-19 patients continue to emerge from China and other part of the world. Herewith, from a systems medicine perspective, the authors analyze those experiences and categorize them into four major treatment principles: (1) focusing on eliminating toxins in the early stage of the disease, (2) tonifying deficiency of the body throughout the entire disease course, (3) treating the affected lung and intestine simultaneously based on visceral interactions, (4) cooling blood and removing blood stasis at the later stage, as well as interpret the rationale of these principles. This is helpful not only in reducing the complexity of promoting the CHM applications to enhance anti-COVID-19 efficacy, but also in ramping out the process of integrating traditional Chinese medicine with modern medical practices.
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